Author

A. Shindo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Saga-Kamo· 2 shared H. Akazawa· 2 shared H. Kadowaki· 2 shared H. Yagi· 2 shared I. Komuro· 2 shared M. Umei· 2 shared N. Takeda· 2 shared Q. Liu· 2 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

A. Saga-Kamo

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

H. Yagi, H. Akazawa, Q. Liu, M. Umei, H. Kadowaki, R. Matsuoka, A. Shindo, S. Okamura, A. Saga-Kamo, N. Takeda, I. Komuro

This study shows that inverse agonist activity of angiotensin II receptor blockers is essential for preventing aortic aneurysm formation in Marfan syndrome mice.

bioRxiv · Dec 21, 2022Pharmacology & Toxicology

Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

H. Yagi, H. Akazawa, Q. Liu, K. Yamamoto, K. Nawata, A. Saga-Kamo, M. Umei, H. Kadowaki, R. Matsuoka, A. Shindo, H. Toko, N. Takeda, M. Ando, H. Yamauchi, N. Takeda, , I. Komuro

This study identifies aberrant mechanosensitive signaling in vascular endothelial cells as a driver of xanthine oxidoreductase activation and ROS generation, contributing to aortic aneurysm formation in Marfan syndrome.

bioRxiv · Jan 30, 2022Pathology