Author

R. Matsuoka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1 Microbiology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 4 Research Focus:host-pathogen & immune response· 3 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

A. Saga-Kamo· 2 shared A. Shindo· 2 shared A. Suzuki· 2 shared C. Yamada· 2 shared D. Drew· 2 shared H. Akazawa· 2 shared H. Kadowaki· 2 shared H. Yagi· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Saga-Kamo

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

PI-(3,5)P2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9

S. Kokane, P. Meier, A. Gulati, R. Matsuoka, T. Pipatpolkai, G. Albano, L. Delemotte, D. Fuster, D. Drew

This study reports cryo-EM structures of NhaA and NHE9 with lipid binding at the dimer interface, showing PI(3,5)P2 stabilizes NHE9 oligomerization and enhances activity.

bioRxiv · Sep 10, 2023 · PreprintBiochemistry

Inhibitors of cannabinoid receptor 1 suppress the cellular entry of Lujo virus

M. Kimura, R. Matsuoka, S. Taniguchi, J. Maruyama, S. Paessler, S. Oka, A. Yamashita, T. Fukuhara, Y. Matsuura, H. Tani

This study identifies CB1 receptor antagonists as inhibitors of Lujo virus entry by suppressing viral membrane fusion and reducing infectivity in vitro.

bioRxiv · May 24, 2023Microbiology

Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

H. Yagi, H. Akazawa, Q. Liu, M. Umei, H. Kadowaki, R. Matsuoka, A. Shindo, S. Okamura, A. Saga-Kamo, N. Takeda, I. Komuro

This study shows that inverse agonist activity of angiotensin II receptor blockers is essential for preventing aortic aneurysm formation in Marfan syndrome mice.

bioRxiv · Dec 21, 2022Pharmacology & Toxicology

Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

H. Yagi, H. Akazawa, Q. Liu, K. Yamamoto, K. Nawata, A. Saga-Kamo, M. Umei, H. Kadowaki, R. Matsuoka, A. Shindo, H. Toko, N. Takeda, M. Ando, H. Yamauchi, N. Takeda, , I. Komuro

This study identifies aberrant mechanosensitive signaling in vascular endothelial cells as a driver of xanthine oxidoreductase activation and ROS generation, contributing to aortic aneurysm formation in Marfan syndrome.

bioRxiv · Jan 30, 2022Pathology

MTCL2 promotes asymmetric microtubule organizationby crosslinking microtubules on the Golgi membrane

R. Matsuoka, M. Miki, S. Mizuno, Y. Ito, C. Yamada, A. Suzuki

This study identifies MTCL2 as a protein that crosslinks microtubules on the Golgi membrane, promoting asymmetric microtubule organization and supporting directional migration.

bioRxiv · Sep 7, 2021 · PreprintCell Biology

Structure and lipid-mediated remodelling mechanism of the Na+/H+ exchanger NHA2

R. Matsuoka, R. Fudim, S. Jung, C. Zhang, A. Bazzone, Y. Chatzikyriakidou, N. Nomura, S. Iwata, L. Orellana, O. Beckstein, D. Drew

This paper reports the cryo-EM structures of NHA2 and reveals its lipid-mediated dimerization mechanism for ion exchange.

bioRxiv · Jul 22, 2021 · PreprintBiophysics

The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster

Y. Yoshinari, H. Kosakamoto, T. Kamiyama, R. Hoshino, R. Matsuoka, S. Kondo, H. Tanimoto, A. Nakamura, F. Obata, R. Niwa

This study identifies Neuropeptide F (NPF) in Drosophila as a sugar-responsive incretin-like hormone that regulates lipid metabolism via glucagon-like and insulin-like hormones.

bioRxiv · May 17, 2021Physiology

MTCL2 promotes asymmetric microtubule organizationby crosslinking microtubules on the Golgi membrane

R. Matsuoka, M. Miki, S. Mizuno, Y. Ito, C. Yamada, A. Suzuki

This study identifies MTCL2 as a protein that crosslinks microtubules on the Golgi membrane, promoting asymmetric microtubule organization and supporting directional migration.

bioRxiv · Aug 19, 2020Cell Biology