Author

I. Komuro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

H. Akazawa· 3 shared N. Takeda· 3 shared A. Saga-Kamo· 2 shared A. Shindo· 2 shared H. Kadowaki· 2 shared H. Yagi· 2 shared M. Umei· 2 shared Q. Liu· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

H. Akazawa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cardiomyocyte transcriptomic signatures in response to Trypanosoma cruzi infection underpin Chagas cardiomyopathy progression.

K. Candray, Y. Nakagama, I. Masamichi, S. Nakagama, E. Tshibangu-Kabamba, N. Takeda, Y. Sugiura, Y. Nitahara, Y. Michimuko-Nagahara, N. Kaku, Y. Onizuka, C.-E. Arias, M. Mejia, K. Alas, S. Pena, , Y. Kido

This study identifies transcriptomic changes in cardiomyocytes infected with different T. cruzi strains, highlighting pathways linked to Chagas cardiomyopathy progression.

bioRxiv · Feb 27, 2023 · PreprintCell Biology

Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

H. Yagi, H. Akazawa, Q. Liu, M. Umei, H. Kadowaki, R. Matsuoka, A. Shindo, S. Okamura, A. Saga-Kamo, N. Takeda, I. Komuro

This study shows that inverse agonist activity of angiotensin II receptor blockers is essential for preventing aortic aneurysm formation in Marfan syndrome mice.

bioRxiv · Dec 21, 2022Pharmacology & Toxicology

Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

H. Yagi, H. Akazawa, Q. Liu, K. Yamamoto, K. Nawata, A. Saga-Kamo, M. Umei, H. Kadowaki, R. Matsuoka, A. Shindo, H. Toko, N. Takeda, M. Ando, H. Yamauchi, N. Takeda, , I. Komuro

This study identifies aberrant mechanosensitive signaling in vascular endothelial cells as a driver of xanthine oxidoreductase activation and ROS generation, contributing to aortic aneurysm formation in Marfan syndrome.

bioRxiv · Jan 30, 2022Pathology

Oxidized LDL but not angiotensin II induces the interaction between LOX-1 and AT1 receptors

L. Lin, N. Zhou, L. Kang, Q. Wang, J. Wu, X. Wang, C. Yang, G. Zhang, Y. Chen, H. Jiang, R. Chen, X. Yang, A. Sun, H. Gong, J. Ren, , Y. Zou

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

bioRxiv · Dec 14, 2020 · PreprintCell Biology