Author

A. Silva-Cayetano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

M. A. Linterman· 3 shared A. Liston· 2 shared J. L. Lee· 2 shared S. Innocentin· 2 shared A. E. Denton· 1 shared A. J. Spencer· 1 shared C. Conceicao· 1 shared C. Noble· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

M. A. Linterman

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3 papers

Recent·Most cited

B cells from aged mice do not have intrinsic defects in affinity maturation

J. L. Lee, S. Innocentin, A. Silva-Cayetano, S. Guillaume, M. A. Linterman

This study shows that B cells from aged mice can undergo affinity maturation similarly to young B cells when their receptor repertoire is constant.

bioRxiv · Apr 24, 2023 · PreprintImmunology

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

A. Silva-Cayetano, W. S. Foster, S. Innocentin, S. Belij-Rammerstorfer, A. J. Spencer, O. T. Burton, S. Fra-Bido, J. L. Lee, N. Thakur, C. Conceicao, D. Wright, J. Barrett, N. Evans-Bailey, C. Noble, D. Bailey, , M. A. Linterman

This study shows that a booster dose of the ChAdOx1 nCoV-19 vaccine increases immune response in aged mice compared to a single dose.

bioRxiv · Oct 27, 2020Immunology

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging

A. E. Denton, A. Silva-Cayetano, J. Dooley, D. L. Hill, E. J. Carr, P. A. Robert, M. Meyer-Hermann, A. Liston, M. A. Linterman

This study shows that aging impairs lymph node stromal cells' ability to respond to vaccination, limiting germinal center formation and antibody production.

bioRxiv · May 7, 2020 · PreprintImmunology