M. A. Linterman

B cells from aged mice do not have intrinsic defects in affinity maturation

This study shows that B cells from aged mice can undergo affinity maturation similarly to young B cells when their receptor repertoire is constant.

Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.

The memory B cell response to influenza vaccination is impaired in older persons

This study shows that older adults have impaired memory B cell responses to influenza vaccination, characterized by reduced somatic hypermutation and positive selection in FCRL5+ atypical memory B cells.

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

This study shows that a booster dose of the ChAdOx1 nCoV-19 vaccine increases immune response in aged mice compared to a single dose.

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging

This study shows that aging impairs lymph node stromal cells' ability to respond to vaccination, limiting germinal center formation and antibody production.