A. J. Spencer

The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 Beta (B.1.351) and other variants of concern in preclinical studies.

Heterologous vaccination regimens with self-amplifying RNA and Adenoviral COVID vaccines induce robust immune responses in mice

This study shows that heterologous vaccination with self-amplifying RNA and adenoviral SARS-CoV-2 vaccines in mice produces stronger antibody and cellular immune responses than single-dose regimens.

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

This study shows that a booster dose of the ChAdOx1 nCoV-19 vaccine increases immune response in aged mice compared to a single dose.

Antigen-specific competitive inhibition of CD4+ T cell recruitment into the primary immune response

The paper investigates how antigen availability and timing affect CD4+ T cell recruitment and response size during the primary immune response.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.