Author

A. Stoeck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Sadruddin· 2 shared A. W. Partridge· 2 shared C. J. Brown· 2 shared C. W. Johannes· 2 shared D. P. Lane· 2 shared S. Kannan· 2 shared S. Ng· 2 shared T. K. Sawyer· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. Sadruddin

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2 papers

Recent·Most cited

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

S. Lim, N. Boyer, N. Boo, C. Huang, G. Venkatachalam, Y.-C. A. Juang, M. Garrigou, K. Kaan, K. M. Peh, A. Sadruddin, P. Gopal, R. Duggal, T. Y. Yuen, S. Ng, S. Kannan, , A. W. Partridge

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

bioRxiv · Sep 11, 2021Biochemistry

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

S. Ng, Y.-C. Juang, A. Chandramohan, H. Y. K. Kaan, A. Sadruddin, T. Y. Yuen, F. J. Ferrer, X. E. C. Lee, L. Xi, C. W. Johannes, C. J. Brown, S. Kannan, P. G. Aronica, N. Berglund, C. S. Verma, , D. P. Lane

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.

bioRxiv · May 21, 2019Biochemistry