Redox signaling regulates breast cancer metastasis via HIF1alpha-stimulated EMT dynamics and metabolic reprogramming
Z. Ren, M. Dharmaratne, H. Liang, O. Benard, M. Morales-Gallego, K. Suyama, A. T. Fard, J. C. Mar, M. Prystowsky, L. Norton, R. B. Hazan
This study shows that GPx2 loss in mammary tumors enhances metastasis through HIF1-driven EMT and metabolic changes, identified via scRNA-seq.
bioRxiv · Aug 29, 2022 · PreprintCancer Biology