Author

S. J. Blanksby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:metabolomics· 5 Research Focus:cancer & tumor microenvironment· 4 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. S. E. Young· 4 shared B. L. J. Poad· 3 shared C. C. Nelson· 3 shared K. D. Tousignant· 3 shared A. P. Bowman· 2 shared D. L. Marshall· 2 shared J. V. Swinnen· 2 shared M. C. Sadowski· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

R. S. E. Young

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cis-vaccenic acid is a key product of stearoyl-CoA desaturase 1 and a critical oncogenic factor in prostate cancer

J. S. Scott, R. S. Young, L.-E. Quek, D. C. Miller, E. S. Evergren, J. Dehairs, I. R. Johnson, D. A. Brooks, M. Loda, A. J. Hoy, S. J. Blanksby, J. V. Swinnen, Z. D. Nassar, L. M. Butler

This study identifies cis-vaccenic acid as a critical oncogenic factor in prostate cancer, showing it rescues cell viability loss from SCD1 inhibition and promotes growth.

bioRxiv · Mar 28, 2024 · PreprintCell Biology

A High-Throughput Data-Independent Acquisition Workflow for Deep Characterisation of the sn-Isomer Lipidome

J. A. Michael, R. S. E. Young, R. Balez, L. J. Jekimovs, D. L. Marshall, B. L. J. Poad, T. W. Mitchell, S. J. Blanksby, C. S. Ejsing, S. R. Ellis

The paper introduces a high-throughput workflow for characterizing sn-isomer lipidomes, identifying more sn-isomer pairs and revealing differences between cell lines.

bioRxiv · Nov 4, 2023 · PreprintCell Biology

Membrane-active peptides escape drug-resistance in cancer

A. H. Benfield, F. Vernen, R. S. E. Young, F. N. Bufi, H. Hammerlindl, D. J. Craik, H. Schaider, N. Lawrence, S. J. Blanksby, S. T. Henriques

This study shows membrane-active peptides can kill drug-resistant melanoma cells without inducing resistance, suggesting their potential as therapeutic agents.

bioRxiv · Oct 27, 2022 · PreprintCancer Biology

Isomeric lipid signatures reveal compartmentalised fatty acid metabolism in cancer

R. S. E. Young, A. P. Bowman, K. D. Tousignant, B. L. J. Poad, J. H. Gunter, L. K. Philp, C. C. Nelson, S. Ellis, R. M. A. Heeren, M. C. Sadowski, S. J. Blanksby

This study uses stable-isotope labelled fatty acids to reveal distinct metabolic fates of exogenous and de novo synthesized fatty acids in cancer cells, showing compartmentalized lipid metabolism.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

Metabolic plasticity in cancer activates apocryphal pathways for lipid desaturation

R. S. E. Young, A. P. Bowman, E. D. Williams, K. D. Tousignant, C. L. Bidgood, V. R. Narreddula, R. Gupta, D. L. Marshall, B. L. Poad, C. C. Nelson, S. R. Ellis, R. M. Heeren, M. Sadowski, S. J. Blanksby

The paper reveals metabolic plasticity in cancer through isomer-resolved lipidomics, identifying apocryphal pathways for lipid desaturation and their impact on lipid structure and function.

bioRxiv · Jun 7, 2020 · PreprintBiochemistry

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

K. D. Tousignant, A. Rockstroh, B. L. J. Poad, A. Talebi, R. R. S. Young, A. T. Fard, R. Gupta, T. Zang, C. Wang, M. L. Lehman, J. V. Swinnen, S. J. Blanksby, C. C. Nelson, M. C. Sadowski

This study identifies therapy-induced lipid uptake and remodeling as drivers of ferroptosis hypersensitivity in prostate cancer, offering new strategies to combat drug resistance.

bioRxiv · Jan 8, 2020Cancer Biology