Author

A. Talebi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:metabolomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. V. Swinnen· 4 shared J. Dehairs· 2 shared A. Foroushani· 1 shared A. Rockstroh· 1 shared A. T. Fard· 1 shared A.-C. Koenig· 1 shared B. L. J. Poad· 1 shared C. C. Nelson· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCancer Biology

J. V. Swinnen

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4 papers

Recent·Most cited

Disrupting peroxisomes alters lipid metabolism in melanoma and uncovers a novel therapeutic vulnerability in combination with MAPK-targeted therapies

F. Huang, F. Cai, M. S. Dahabieh, K. Gunawardena, A. Talebi, J. Dehairs, F. El-Turk, J. Y. Park, C. Goncalves, N. Gagnon, J. Su, P. Gaub, J.-S. Joyal, J. J. Mitchell, J. V. Swinnen, , S. V. del Rincon

This paper identifies a metabolic vulnerability in melanoma cells by disrupting peroxisomes and shows that combining this with MAPK-targeted therapies enhances anti-tumor effects.

bioRxiv · Oct 25, 2022 · PreprintCancer Biology

Alpha-ketoglutarate inhibits Regulatory T cell differentiation by coupling lipidome remodelling to mitochondrial metabolism

M. I. Matias, C. S. Yong, A. Foroushani, E. Sezgin, K. R. Levental, A. Talebi, C. Mongellaz, J. Dehair, M. Wong, S. Kinet, V. S. Zimmermann, I. Levental, L. Yvan-Charvet, J. v. Swinnen, S. Muljo, , N. Taylor

This study shows that alpha-ketoglutarate inhibits regulatory T cell differentiation by altering lipid metabolism and mitochondrial function.

bioRxiv · Aug 24, 2020 · PreprintImmunology

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

K. D. Tousignant, A. Rockstroh, B. L. J. Poad, A. Talebi, R. R. S. Young, A. T. Fard, R. Gupta, T. Zang, C. Wang, M. L. Lehman, J. V. Swinnen, S. J. Blanksby, C. C. Nelson, M. C. Sadowski

This study identifies therapy-induced lipid uptake and remodeling as drivers of ferroptosis hypersensitivity in prostate cancer, offering new strategies to combat drug resistance.

bioRxiv · Jan 8, 2020Cancer Biology

Cell density-dependent ferroptosis in breast cancer is induced by accumulation of polyunsaturated fatty acid-enriched triacylglycerides

E. Panzilius, F. Holstein, J. Dehairs, M. Planque, C. von Toerne, A.-C. Koenig, S. Doll, M. Bannier-Helaouët, H. M. Ganz, S. M. Hauck, A. Talebi, J. V. Swinnen, S.-M. Fendt, J. P. Friedmann Angeli, M. Conrad, C. H. Scheel

This study shows that low cell density in breast cancer cells increases ferroptosis sensitivity by promoting PUFA-enriched TAG accumulation and reducing lipid desaturation.

bioRxiv · Oct 1, 2019 · PreprintCancer Biology