Author

K. D. Tousignant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:metabolomics· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

C. C. Nelson· 3 shared S. J. Blanksby· 3 shared A. P. Bowman· 2 shared B. L. J. Poad· 2 shared M. C. Sadowski· 2 shared R. Gupta· 2 shared R. S. E. Young· 2 shared A. Rockstroh· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

C. C. Nelson

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Author profile →

3 papers

Recent·Most cited

Isomeric lipid signatures reveal compartmentalised fatty acid metabolism in cancer

R. S. E. Young, A. P. Bowman, K. D. Tousignant, B. L. J. Poad, J. H. Gunter, L. K. Philp, C. C. Nelson, S. Ellis, R. M. A. Heeren, M. C. Sadowski, S. J. Blanksby

This study uses stable-isotope labelled fatty acids to reveal distinct metabolic fates of exogenous and de novo synthesized fatty acids in cancer cells, showing compartmentalized lipid metabolism.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

Metabolic plasticity in cancer activates apocryphal pathways for lipid desaturation

R. S. E. Young, A. P. Bowman, E. D. Williams, K. D. Tousignant, C. L. Bidgood, V. R. Narreddula, R. Gupta, D. L. Marshall, B. L. Poad, C. C. Nelson, S. R. Ellis, R. M. Heeren, M. Sadowski, S. J. Blanksby

The paper reveals metabolic plasticity in cancer through isomer-resolved lipidomics, identifying apocryphal pathways for lipid desaturation and their impact on lipid structure and function.

bioRxiv · Jun 7, 2020 · PreprintBiochemistry

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

K. D. Tousignant, A. Rockstroh, B. L. J. Poad, A. Talebi, R. R. S. Young, A. T. Fard, R. Gupta, T. Zang, C. Wang, M. L. Lehman, J. V. Swinnen, S. J. Blanksby, C. C. Nelson, M. C. Sadowski

This study identifies therapy-induced lipid uptake and remodeling as drivers of ferroptosis hypersensitivity in prostate cancer, offering new strategies to combat drug resistance.

bioRxiv · Jan 8, 2020Cancer Biology