Author

H.-J. Kang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:rat· 2 Research Focus:drug response / drug discovery· 1 Organism:non-human primate· 1

Frequent Co-Authors

R. K. Plemper· 4 shared C. M. Lieber· 3 shared J.-J. Yoon· 3 shared M. G. Natchus· 3 shared R. Cox· 3 shared A. Kolykhalov· 2 shared A. L. Greninger· 2 shared E. B. Sobolik· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

R. K. Plemper

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Influenza A virus resistance to 4-fluorouridine coincides with viral attenuation in vitro and in vivo

C. M. Lieber, H.-J. Kang, M. Aggarwal, N. A. P. Lieberman, E. B. Sobolik, J.-J. Yoon, M. G. Natchus, R. Cox, A. L. Greninger, R. K. Plemper

This study identifies mutations conferring resistance to 4-fluorouridine in influenza viruses and shows that resistant variants are attenuated in vivo and can be overcome by higher drug doses.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Intestinal microbiota programming of alveolar macrophages influences severity of respiratory viral infection

A. T. Gewirtz, V. Ngo, C. Lieber, R. K. Plemper, K. Sakomoto, M. P. Kuczma, H.-j. Kang

The paper shows that segmented filamentous bacteria reprogram alveolar macrophages to enhance non-inflammatory defense against respiratory viruses.

bioRxiv · Sep 21, 2023Immunology

Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

R. K. Plemper, R. Cox, J. D. Wolf, N. A. P. Lieberman, C. M. Lieber, H.-J. Kang, Z. M. Sticher, J.-J. Yoon, M. K. Andrews, M. Govindarajan, R. E. Krueger, E. B. Sobolik, M. G. Natchus, A. Gewirtz, R. deSwart, , A. L. Greninger

This study shows that prior respiratory virus infections worsen measles severity in ferrets and that antiviral treatment can mitigate immune amnesia and disease outcomes regardless of treatment timing.

bioRxiv · Sep 1, 2023Microbiology

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

C. M. Lieber, M. Aggarwal, J.-J. Yoon, R. Cox, J. Sourimant, M. Toots, H.-J. Kang, S. K. Johnson, C. A. Jones, Z. M. Sticher, A. Kolykhalov, M. T. Sindaine, S. M. Tompkins, O. Planz, G. R. Painter, , R. K. Plemper

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

bioRxiv · Nov 5, 2022 · PreprintMicrobiology