Author

A. Tsourkas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Z. Cheng· 2 shared A. Amirshaghaghi· 1 shared A. Majumder· 1 shared B. Channer· 1 shared B. Chhay· 1 shared C. A. Hunter· 1 shared C. Espy· 1 shared C. Nuss· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersPathology

Z. Cheng

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

sPLA2 inhibitor-loaded nanoparticles mitigate spontaneous osteoarthritis in guinea pigs

Q. Liang, Q. He, Y. Xu, Y. Dai, C. Nuss, J. D. Eekhoff, S. Awasthi, J. Liang, T. Sun, M. P. Duffy, V. Bhangui, A. Tsourkas, Z. Cheng, Ling Qin

This study shows that sPLA2 inhibitor-loaded nanoparticles reduce spontaneous osteoarthritis in guinea pigs by decreasing cartilage damage and inflammation.

bioRxiv · Nov 9, 2026 · PreprintPathology

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects

S. Omo-Lamai, Y. Wang, M. N. Patel, E.-o. Essien, M. Shen, A. Majumder, C. Espy, J. Wu, B. Channer, M. P. Tobin, S. Murali, T. E. Papp, R. Maheshwari, L. Wang, L. S. Chase, , J. S. Brenner

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

bioRxiv · Apr 16, 2024 · PreprintBioengineering

High-throughput single-cell, single-mitochondrial DNA assay using hydrogel droplet microfluidics

J. Park, P. S. Kadam, Y. Atiyas, B. Chhay, A. Tsourkas, J. H. Eberwine, D. A. Issadore

This paper introduces a high-throughput method for single-cell, single-mtDNA analysis using agarose-based droplet microfluidics, achieving high mtDNA retention and enabling scalable analysis.

bioRxiv · Jan 29, 2024Bioengineering

Phospholipase A2 inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression

Y. Wei, L. Yan, L. Luo, T. Gui, A. Amirshaghaghi, T. You, a. tsourkas, L. Qin, z. cheng

This study develops sPLA2 inhibitor-loaded micellar nanoparticles that reduce inflammation and slow osteoarthritis progression in human and mouse models.

bioRxiv · Jan 15, 2021Bioengineering