Author

S. Awasthi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

M. Mayer· 2 shared A. El-Kenawi· 1 shared A. Keske· 1 shared A. Tsourkas· 1 shared A. Venugopalan· 1 shared B. Ruffell· 1 shared C. M. Cultraro· 1 shared C. Nuss· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiophysics

M. Mayer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

sPLA2 inhibitor-loaded nanoparticles mitigate spontaneous osteoarthritis in guinea pigs

Q. Liang, Q. He, Y. Xu, Y. Dai, C. Nuss, J. D. Eekhoff, S. Awasthi, J. Liang, T. Sun, M. P. Duffy, V. Bhangui, A. Tsourkas, Z. Cheng, Ling Qin

This study shows that sPLA2 inhibitor-loaded nanoparticles reduce spontaneous osteoarthritis in guinea pigs by decreasing cartilage damage and inflammation.

bioRxiv · Nov 9, 2026 · PreprintPathology

Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution

S. Awasthi, C. Ying, J. Li, M. Mayer

This paper uses nanopore measurements to determine the size and shape of single α-synuclein oligomers in solution, revealing stable sub-populations with specific monomer counts.

bioRxiv · Jan 9, 2023Biophysics

Site-specific C-terminal fluorescent labeling of Tau protein

L. Bryan, S. Awasthi, Y. Li, P. N. Nirmalraj, S. Balog, J. Yang, M. Mayer

This study develops a method to fluorescently label Tau protein at its C-terminus to avoid disrupting its microtubule-binding region, showing no significant effect on its aggregation properties.

bioRxiv · Jun 7, 2022Biophysics

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

A. El-Kenawi, W. Dominguez-Viqueira, M. Liu, S. Awasthi, A. Keske, K. K. Steiner, L. Noel, J. Dhillon, R. J. Gillies, K. Yamoah, X. Yu, J. Koomen, R. A. Gatenby, B. Ruffell

This study shows that macrophage-derived cholesterol supports androgen biosynthesis in prostate cancer, contributing to resistance to therapy, and that targeting macrophages can enhance treatment outcomes.

bioRxiv · Mar 24, 2021Cancer Biology

Quantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V

X. Zhang, K. D. Nguyen, P. Rudnick, N. Roper, E. Kawaler, T. K. Maity, S. Awasthi, S. Gao, R. Biswas, A. Venugopalan, C. M. Cultraro, D. Fenyo, U. Guha

The paper uses quantitative mass spectrometry to analyze proteomic and phosphoproteomic changes in metastatic lung adenocarcinoma and validates a novel somatic mutation CDK12-G879V associated with chemotherapy sensitivity.

bioRxiv · Aug 22, 2018Cancer Biology