Author

A. V. Grassetti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

S. A. Gerber· 2 shared A. L. Greenleaf· 1 shared B. Sharma· 1 shared D. S. Day· 1 shared E. Chipumuro· 1 shared G.-C. Yuan· 1 shared H. Huang· 1 shared J. H. Davis· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

S. A. Gerber

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Author profile →

3 papers

Recent·Most cited

Application of monolayer graphene to cryo-electron microscopy grids for high-resolution structure determination

A. V. Grassetti, M. B. May, J. H. Davis

This paper describes a method to apply monolayer graphene to cryo-EM grids to improve sample preparation and demonstrates its effectiveness in achieving high-resolution structural analysis.

bioRxiv · Jul 28, 2023Biochemistry

Quantitative phosphoproteomics reveals regulatory state dependent efficacy of chemical Cdk1 inhibition and distinct Cdk5 complexes as novel Wee1 substrates

A. V. Grassetti, R. Hards, S. A. Gerber

This study uses phosphoproteomics to show Wee1-dependent phosphorylation of Cdk1-cyclin B enhances RO3306 inhibition and identifies Cdk5 complexes as new Wee1 substrates.

bioRxiv · Sep 27, 2021 · PreprintCell Biology

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

M. Krajewska, R. Dries, A. V. Grassetti, S. Dust, Y. Gao, H. Huang, B. Sharma, D. S. Day, N. Kwiatkowski, M. Pomaville, O. Dodd, E. Chipumuro, T. Zhang, A. L. Greenleaf, G.-C. Yuan, , R. E. George

This study shows CDK12 inhibition causes premature cleavage and polyadenylation in long DNA damage response genes, linked to their length and polyadenylation site distribution.

bioRxiv · Nov 30, 2018Cancer Biology