J. H. Davis

Rapid structural analysis of bacterial ribosomes in situ

The paper develops a rapid in situ cryo-ET workflow for bacterial ribosome structure analysis, achieving sub-nm resolution in E. coli within 10 days.

Application of monolayer graphene to cryo-electron microscopy grids for high-resolution structure determination

This paper describes a method to apply monolayer graphene to cryo-EM grids to improve sample preparation and demonstrates its effectiveness in achieving high-resolution structural analysis.

The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery

This paper presents a cryo-EM structure of the SspB adaptor bound to ClpXP and a tagged substrate, revealing structural changes in ClpX and its interaction with ClpP during substrate delivery.

A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation

The paper presents cryo-EM structures of E. coli ClpXP, showing that a closed axial channel in ClpX enhances degradation specificity by preventing non-specific substrate entry.

Uncovering structural ensembles from single particle cryo-EM data using cryoDRGN

This paper introduces cryoDRGN, a deep generative model for cryo-EM density maps, and provides a protocol for analyzing its results.

KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion

The paper identifies KsgA's role in ribosome assembly by using cryo-EM and machine learning to show it proofreads and disassembles immature ribosomal subunits, improving assembly fidelity.

UVC Inactivation of Black Mold is Wavelength-Dependent, and its Growth in HVAC Systems is Preventable Using Periodic Dosing with commercially available UVC LEDs

This study shows that UVC inactivation of black mold is wavelength-dependent and demonstrates that periodic dosing with UVC LEDs can prevent mold growth in HVAC systems.