Author

A. Ventura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Shepard· 1 shared C. Crish· 1 shared C. Mastroleo· 1 shared C. R. Antonescu· 1 shared D. B. Udy· 1 shared D. Dongliang· 1 shared D. Lester· 1 shared D. Pradella· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. Shepard

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Author profile →

3 papers

Recent·Most cited

An autochthonous model of lung cancer in the Naked Mole-Rat (Heterocephalus glaber)

J. Kissil, A. Shepard, S. Troutman, S. Hoxha, D. Lester, W. Khaled, E. S. J. Smith, T. Park, R. Buffenstein, D. Dongliang, M. S. J. Teng, C. Crish, K. Tsai, E. Flores, A. Ventura

This study develops an endogenous lung cancer model in naked mole-rats, showing tumor initiation more closely resembles human tumors than in mice.

bioRxiv · Aug 28, 2023Cancer Biology

Immortalization and transformation of primary cells mediated by engineered ecDNAs

D. Pradella, M. Zhang, R. Gao, Y. A. Melissa, K. M. Gluchowska, Y. Cendon Florez, T. Mishra, G. La Rocca, M. Weigl, Z. Jiao, H. H. M. Nguyen, F. Grimm, M. Lisi, C. Mastroleo, K. Chen, , A. Ventura

This paper describes a method to engineer large focal amplifications in primary cells using ecDNAs, showing they promote proliferation and transformation.

bioRxiv · Jun 25, 2023 · PreprintCancer Biology

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

J. T. Polaski, D. B. Udy, L. F. Escobar-Hoyos, G. Askan, S. D. Leach, A. Ventura, R. Kannan, R. K. Bradley

This study investigates UPF1 mutations in pancreatic adenosquamous carcinoma, finding they are likely non-pathogenic and not a common driver of the disease.

bioRxiv · Aug 14, 2020Cancer Biology