Author

E. S. J. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Physiology· 3 Pharmacology & Toxicology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:clustering· 2 Assay:electrophysiology· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. C. Bulmer· 3 shared J. R. Hockley· 3 shared F. Welsh· 2 shared J. P. Higham· 2 shared K. H. Barker· 2 shared L. A. Pattison· 2 shared L. W. Paine· 2 shared P. Urriola-Munoz· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersPhysiology

D. C. Bulmer

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate

M. Y. Meng, L. W. Paine, D. Sagnat, I. Bello, S. Oldroyd, F. Javid, M. T. Harper, J. R. Hockley, E. S. J. Smith, R. M. Owens, L. Alric, E. Buscail, F. Welsh, N. Vergnolle, D. C. Bulmer

This study shows TRPV4 activation in the colon increases afferent activity via mucosal release of ATP and glutamate, suggesting a target for visceral pain treatment.

bioRxiv · Apr 12, 2024Pharmacology & Toxicology

Intestinal barrier function in the naked mole-rat: an emergent model for gastrointestinal insights

J. Aguilera-Lizarraga, A. Ritoux, D. Bulmer, E. S. J. Smith

This study investigates the intestinal barrier function in naked mole-rats, finding reduced gut permeability and diminished secretory responses compared to mice.

bioRxiv · Jan 17, 2024Physiology

Regenerative cell turnover coupled to a tumor-hostile niche protects naked mole-rats from cancer

M. Behm, P. Baeza-Centurion, S. Weser, V. F. Busa, P. Zafferani, L. Penso-Dolfin, F. J. Botey, S. Delaunay, N. Hirschmuller, B. Berthet, M.-L. Koch, S. Del Prete, M. Bekavac, D. Sohn, L. Penteskoufi, , M. Frye

This study identifies a tumor-suppressive strategy in naked mole-rats that couples regenerative cell turnover with a tumor-hostile stromal niche to prevent cancer.

bioRxiv · Oct 10, 2023 · PreprintCancer Biology

GPR35 inhibits TRPA1-mediated colonic afferent hypersensitivity through suppression of Substance P release

R. A. Gupta, J. P. Higham, P. Urriola-Munoz, K. H. Barker, L. W. Paine, J. Ghooraroo, J. R. Hockley, T. Rahman, E. S. J. Smith, A. J. Brown, R. Suzuki, D. C. Bulmer

This paper identifies GPR35 as a target for non-opioid analgesics by showing it inhibits TRPA1-mediated colonic hypersensitivity through suppression of Substance P release.

bioRxiv · Sep 12, 2023 · PreprintPhysiology

An autochthonous model of lung cancer in the Naked Mole-Rat (Heterocephalus glaber)

J. Kissil, A. Shepard, S. Troutman, S. Hoxha, D. Lester, W. Khaled, E. S. J. Smith, T. Park, R. Buffenstein, D. Dongliang, M. S. J. Teng, C. Crish, K. Tsai, E. Flores, A. Ventura

This study develops an endogenous lung cancer model in naked mole-rats, showing tumor initiation more closely resembles human tumors than in mice.

bioRxiv · Aug 28, 2023Cancer Biology

Sensitisation of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity

K. H. Barker, J. P. Higham, L. A. Pattison, I. P. Chessell, F. Welsh, E. S. J. Smith, D. C. Bulmer

This study shows IL-13 sensitizes colonic nociceptors via JAK and p38 MAPK signaling, offering therapeutic targets for visceral pain in gastrointestinal diseases.

bioRxiv · Oct 26, 2022 · PreprintPhysiology

Dysregulation of ADAM10 shedding activity in naked mole-rat fibroblasts is due to deficient phosphatidylserine externalisation

P. Urriola-Munoz, L. A. Pattison, E. S. J. Smith

This study shows that ADAM10 shedding activity is impaired in naked mole-rat fibroblasts due to deficient phosphatidylserine externalization, which can be rescued by overexpressing ANO6.

bioRxiv · Jun 9, 2022 · PreprintCancer Biology

Gut Reaction: The Impact of a Film on Public Understanding of Gastrointestinal Conditions

D. M. Gomes, A. Loth, J. R. Hockley, E. S. J. Smith

This paper evaluates a short film's impact on public understanding and stigma around chronic gastrointestinal conditions through surveys and interviews.

bioRxiv · Sep 5, 2021Scientific Communication & Education