Author

S. D. Leach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:imaging· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. L. Massa· 2 shared G. Askan· 2 shared H. Chintalapudi· 2 shared A. Cardenas· 1 shared A. P. Makohon-Moore· 1 shared A. Ventura· 1 shared B. Curry· 1 shared C. A. Iacobuzio-Donahue· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

A. L. Massa

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A common set of structurally distinct endogenous retroviruses predict survival in multiple human tumor types

A. L. Massa, H. Chintalapudi, E. C. Coppenbarger, J. M. Peterson, W. N. Moss, H. R. Frost, S. D. Leach

The paper identifies a set of endogenous retroviruses (ERVs) whose expression predicts survival in multiple cancers and is linked to immune response signatures.

bioRxiv · Feb 7, 2024 · PreprintCancer Biology

Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human System

I. Jubber, D. R. Morhardt, J. Griffin, M. G. Cumberbatch, M. Glover, Y. Zheng, I. Rehman, C. A. Loynes, S. A. Hussain, S. D. Leach, S. Renshaw, V. T. Cunliffe, J. W. Catto

The paper identifies homology between zebrafish and human distal urinary tract anatomy, including a functional urinary bladder in adult zebrafish.

bioRxiv · Jan 30, 2023 · PreprintEvolutionary Biology

Pancreatic cancer prognosis is predicted by a novel ATAC-array technology for assessing chromatin accessibility

S. Dhara, S. Chhangawala, H. Chintalapudi, G. Askan, V. Aveson, A. L. Massa, L. Zhang, A. P. Makohon-Moore, N. Lecomte, J. P. Melchor, J. Bermeo, A. Cardenas, S. Sinha, D. Glassman, R. Nicolle, , S. D. Leach

The paper develops ATAC-Array, a low-cost chromatin accessibility assay, and shows it predicts pancreatic cancer prognosis based on chromatin accessibility patterns.

bioRxiv · Jan 21, 2021Cancer Biology

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

J. T. Polaski, D. B. Udy, L. F. Escobar-Hoyos, G. Askan, S. D. Leach, A. Ventura, R. Kannan, R. K. Bradley

This study investigates UPF1 mutations in pancreatic adenosquamous carcinoma, finding they are likely non-pathogenic and not a common driver of the disease.

bioRxiv · Aug 14, 2020Cancer Biology

Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner

C. J. Latario, L. W. Schoenfeld, C. L. Howarth, L. E. Pickrell, F. Begum, D. A. Fischer, O. Grbovic-Huezo, S. D. Leach, Y. Sanchez, K. D. Smith, H. N. Higgs

This study identifies tumor microtubes (TMTs) in pancreatic cancer cells, showing they depend on the Arp2/3 complex for assembly and differ structurally from tunneling nanotubes.

bioRxiv · Nov 14, 2019Cell Biology