R. Kannan

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

Characterization and contribution of RPE senescence to Age-related macular degeneration in Tnfrsf10 knock out mice

This study investigates how RPE senescence contributes to AMD using TNFRSF10A silenced hRPE cells and Tnfrsf10 KO mice, showing increased p16 and p21 expression and metabolic changes.

Enhanced epithelial to mesenchymal transition and chemoresistance in advanced Retinoblastoma tumors is driven by miR-181a

This study identifies miR-181a-5p as a regulator of EMT and chemoresistance in advanced retinoblastoma by reversing drug resistance through targeting ZEB1 and SNAI2.

Predicting systemic and pulmonary tissue barrier concentration of orally inhaled drug products

This paper develops a multiscale computational model to predict the systemic and pulmonary tissue concentration of orally inhaled drugs, validated with budesonide and fluticasone propionate.

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

This study investigates UPF1 mutations in pancreatic adenosquamous carcinoma, finding they are likely non-pathogenic and not a common driver of the disease.

Antibodies that potently inhibit or enhance SARS-CoV-2 spike protein-ACE2 interaction isolated from synthetic single-chain antibody libraries

Abl signaling shapes the intrinsic fluctuations of actin to direct growth of a pioneer axon in Drosophila

This study shows Abl signaling modulates actin fluctuations in Drosophila pioneer axons to drive directed growth by promoting protrusions in leading intervals and collapsing them in lagging intervals.