Author

A. W. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. L. Herneisen· 2 shared S. Lourido· 2 shared A. Bazarna· 1 shared A. Paschen· 1 shared B. Scheffler· 1 shared C. Neander· 1 shared C. Soun· 1 shared C. Yip· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

A. L. Herneisen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

A. W. Chan, M. Broncel, E. Yifrach, N. R. Haseley, S. Chakladar, E. Andree, A. L. Herneisen, E. Shortt, M. Treeck, S. Lourido

This study identifies CDPK1 targets in Toxoplasma gondii, revealing a trafficking adaptor complex that regulates microneme exocytosis and host cell invasion.

bioRxiv · Jan 11, 2023 · PreprintMicrobiology

De novo mapping of the apicomplexan Ca2+-responsive proteome

A. L. Herneisen, Z.-H. Li, A. W. Chan, S. N. Moreno, S. Lourido

The paper maps the Ca2+-responsive proteome of T. gondii using phosphoproteomics and thermal proteome profiling, identifying both known and novel proteins involved in Ca2+ signaling pathways.

bioRxiv · May 25, 2022 · PreprintMicrobiology

Progranulin promotes immune evasion of pancreatic adenocarcinoma through regulation of MHCI expression

P. F. Cheung, J. Yang, K. Krengel, K. Althoff, C. Yip, E. H. Siu, L. W. Ng, K. S. Lang, L. Cham, D. R. Engel, C. Soun, I. Cima, B. Scheffler, J. K. Striefler, M. Sinn, , J. T. Siveke

This study shows that tumor-derived progranulin (PGRN) promotes immune evasion in pancreatic ductal adenocarcinoma by reducing MHC class I expression, and blocking PGRN enhances immune response and slows tumor progression.

bioRxiv · Feb 24, 2021 · PreprintCancer Biology