Author

A. Z. L. Shih

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Chaudhry· 1 shared B. Hoffman· 1 shared B. Vanderkruk· 1 shared C. B. Verchere· 1 shared D. J. Pasula· 1 shared D. S. Luciani· 1 shared R. Shi· 1 shared T. Willnow· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

A. Chaudhry

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2 papers

Recent·Most cited

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

A. Z. L. Shih, Y.-C. Chen, C. B. Verchere, T. Willnow

This study shows SORLA reduces islet amyloid deposition by mediating endocytic uptake of proIAPP, preventing cell death in pancreatic beta cells.

bioRxiv · Apr 21, 2022Cell Biology

Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excess

D. J. Pasula, R. Shi, B. Vanderkruk, A. Z. L. Shih, Y. Zou, A. Chaudhry, B. Hoffman, D. S. Luciani

This study shows that Bcl-xL prevents mitochondrial dysfunction in beta-cells under chronic glucose stress by limiting mitochondrial ROS and maintaining gene expression.

bioRxiv · Oct 25, 2021 · PreprintCell Biology