D. S. Luciani

Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5 in mice

This study identifies GRK5 as a regulator of pancreatic β-cell proliferation through phosphorylation of HDAC5, linking it to type 2 diabetes pathogenesis.

Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excess

This study shows that Bcl-xL prevents mitochondrial dysfunction in beta-cells under chronic glucose stress by limiting mitochondrial ROS and maintaining gene expression.

Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice

This study shows that H3K4me3 is essential for maintaining beta cell function in adult mice by supporting gene expression for insulin biosynthesis and glucose responsiveness.

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress

This study shows Bax and Bak control survival and reduce early ER stress in β-cells under glucolipotoxic stress through non-apoptotic and apoptotic mechanisms.

A pipeline for multidimensional confocal analysis of mitochondrial morphology, function and dynamics in pancreatic β-cells

The paper develops a pipeline and ImageJ plugin for 2D/3D quantification of mitochondrial morphology and dynamics in mouse β-cells using standard confocal microscopy.