Author

Aaron Kakazu

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Assay:imaging· 4 Organism:mouse· 4 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Minmin Yao· 4 shared Wenzhen DuaniD· 4 shared Yuxiao OuyangiD· 4 shared Ruoxuan LiiD· 3 shared Zhiliang WeiiD· 3 shared Haitong WangiD· 2 shared Hanzhang LuiD· 2 shared Lida DuiD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersNeuroscience

Minmin Yao

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4 papers

Recent·Most cited

Progressively reduced cerebral oxygen metabolism and elevated plasma NfL levels in the zQ175DN mouse model of Huntington disease

Qian Wu, Minmin Yao, Hongshuai Liu, Aaron Kakazu, Yuxiao Ouyang, Chang Liu, Ruoxuan Li, Fan Yang, Anqi Wang, Sharmane Surasinghe, Damien Gerochi, Barbara Baldo, Stefanie Jahn, Haiying Tang, Hanzhang Lu, , Wenzhen Duan

This study characterizes the progression of the zQ175DN mouse model of Huntington disease, identifying early biomarkers like brain volume loss and plasma NfL elevation.

Experimental Neurology · Sep 12, 2025Peer-reviewedNeuroscience

Cell type-specific contributions to impaired blood-brain barrier and cerebral metabolism in presymptomatic 5XFAD mice

Minmin Yao, Na Sun, Raleigh M. Linville, Zhiliang Wei, Aaron Kakazu, Yuxiao Ouyang, Ruoxuan Li, Lida Du, Haitong Wang, Yuan Zhou, Yanli Jiang, Ziqin Zhang, Anna Li, Hanzhang Lu, Jiadi Xu, , Wenzhen Duan

The paper identifies cell type-specific transcriptomic changes in 5XFAD mice that link BBB dysfunction and metabolic dysregulation to early AD pathogenesis.

bioRxiv · Apr 23, 2025 · PreprintNeuroscience

Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation

Jayvik Joshi, Minmin Yao, Aaron Kakazu, Yuxiao Ouyang, Wenzhen Duan, Manisha Aggarwal

This study uses quantitative susceptibility mapping to distinguish microgliosis and tau deposition in a mouse model of tauopathy by analyzing paramagnetic and diamagnetic susceptibility components.

Imaging Neuroscience · Jan 1, 2025Peer-reviewedNeuroscience

Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model

Minmin Yao, Zhiliang Wei, Jonathan Scharff Nielsen, Yuxiao Ouyang, Aaron Kakazu, Haitong Wang, Lida Du, Ruoxuan Li, Tiffany Chu, Susanna Scafidi, Hanzhang Lu, Manisha Aggarwal, Wenzhen Duan

This study shows that senolytic therapy with D+Q preserves BBB integrity and improves cognitive function in a tauopathy mouse model.

Neurobiology of Disease · Oct 21, 2024Peer-reviewedNeuroscience