Nanomedicines targeting signaling of protease-activated receptor 2 in organelles provide sustained analgesia
Shavonne L. Teng, Rocco Latorre, Divya Bhansali, Parker K. Lewis, Rachel E. Pollard, Chloe J. Peach, Badr Sokrat, Gokul Sriman Thanigai Arasu, Tracy Chiu, Dane D. Jensen, Nestor Nivardo Jiménez-Vargas, Abby Mocherniak, Lucas T. Parreiras‐e‐Silva, Michel Bouvier, Matthew Bogyo, , Nigel W. Bunnett
This study shows that targeting protease-activated receptor 2 (PAR2) signaling in organelles using nanomedicines provides sustained analgesia in preclinical models of inflammatory bowel disease.
Proceedings of the National Academy of Sciences · Oct 7, 2025Peer-reviewedPhysiology