Badr Sokrat

This study shows that EP4 receptor internalization and compartmentalized signaling in DRG nociceptors mediate PGE2-induced pain, suggesting new strategies for inflammatory pain management.

This study shows that PAR2 endosomal signaling amplifies and sustains histamine-induced pain in IBS by maintaining H1R activity.

This study shows that targeting protease-activated receptor 2 (PAR2) signaling in organelles using nanomedicines provides sustained analgesia in preclinical models of inflammatory bowel disease.