Author

Adam H. Libby

University of Virginia Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

5· 2 shared Madeleine L. Ware· 2 shared Olivia L. MurtaghiD· 2 shared AeRyon KimiD· 1 shared Aizhen Xiao· 1 shared Benjamin W. PurowiD· 1 shared Bissan Al‐LazikaniiD· 1 shared Chin‐Yuan ChangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

5

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CysLENS: Interpretable signatures of cysteine ligandability from enantiomeric chemoproteomics and protein language models

Sameek Singh, Maja Wierzbinska, Konika Konika, Adam H. Libby, Yue Dou, Christopher T. Prevost, Jie Peng, Jetze J. Tepe, Tianlong Chen, John Hackett Bushweller, Tian Zhang

CysLENS identifies cysteine ligandability by integrating chemoproteomic data with protein language models to prioritize stereoselective interactions.

bioRxiv · Aug 27, 2026 · PreprintBiochemistry

A Chemoproteomic Atlas of the Human Purine Interactome for Regioselective Ligand Discovery

Zhihong Li, Hsiao-Kuei Tsai, Adam H. Libby, Michael W. Founds, Olivia L. Murtagh, Madeleine L. Ware, David M. Leace, 5, Phillip W. Gingrich, Bissan Al‐Lazikani, Chin‐Yuan Chang, Ku‐Lung Hsu

The paper develops a chemoproteomics platform to map the human purine interactome and identifies a regioselective ligand for ACAT2 with potential therapeutic applications in cancer.

Nature Communications · Jun 5, 2026Peer-reviewedBiochemistry

Stereoselective Degradation of Diacylglycerol Kinases Potentiate T cell Activation and Tumor Cell Cytotoxicity

Minhaj Shaikh, Surya Pravo Mookherjee, Claire C. Weckerly, Adam H. Libby, Aizhen Xiao, Yunge Zhao, Sagar D. Vaidya, AeRyon Kim, Zhihong Li, Madeleine L. Ware, Michelle Marants, Olivia L. Murtagh, 5, Timothy N. J. Bullock, Benjamin W. Purow, , Ku-Lung Hsu

This study identifies a stereoselective DGK inhibitor that enhances T cell activation and tumor cell cytotoxicity through proteasome-dependent degradation of DGK.

bioRxiv · Dec 12, 2025 · PreprintBiochemistry