Jonathan M. Grimes

This study identifies a triple-layer protein lattice within coronavirus spherules and confirms a molecular pore in DMVs, providing insights into coronavirus replication structures.

This study identifies promoter-dependent nuclear export as a mechanism for influenza A virus to select its genome for packaging into virions.

This study characterizes the structure and function of CCHFV RNA-dependent RNA polymerase, revealing its unique features and antiviral susceptibility.

This study shows that the PP1 phosphatase complex coordinates pre-mRNA 3' end processing and RNA polymerase II transcription termination through interactions with PNUTS and Symplekin.

This study shows that Spt5 enhances Xrn2 activity to facilitate Pol II transcription termination and prevent non-coding transcript expression.

This study characterizes the structural and functional interaction between influenza A virus RNA polymerase and host RNA Polymerase II CTD, identifying key residues and their roles in transcription and replication.