Silvia Cases‐Cunillera

Single-cell profiling reveals tumor grade-dependent immune remodeling in BRAFV600E-driven glioneuronal tumors

This study uses single-cell transcriptomics to show that BRAFV600E-driven glioneuronal tumors have distinct immune profiles based on tumor grade, with SPP1 playing a key role in high-grade tumors.

Epileptogenesis dynamics driven by peritumoral circuit rewiring in gangliogliomas

This study shows that gangliogliomas induce developmental changes in cortical networks, leading to seizure dynamics that shift from neonatal to adult stages, with age-specific therapeutic implications.

NKCC1 as a signaling hub regulating KCC2 stability, chloride homeostasis, and seizure susceptibility

The paper identifies NKCC1 as a signaling hub that regulates KCC2 stability and chloride homeostasis, showing that peptides targeting NKCC1 can reduce seizure frequency in epilepsy.

Neuronal extracellular vesicles mediate BDNF-dependent dendritogenesis and synapse maturation via microRNAs

This study shows neuronal extracellular vesicles transfer microRNAs to mediate BDNF-dependent dendritogenesis and synapse maturation in hippocampal neurons.

Ste20-like kinase is critical for inhibitory synapse maintenance and its deficiency confers a developmental dendritopathy

This study identifies SLK as critical for dendritic complexity and inhibitory synapse maintenance in neurons, with implications for human cortical malformations.

Heterogeneity and excitability of BRAFV600E-induced tumors is determined by PI3K/mTOR-signaling state and Trp53-loss

This study identifies how PI3K/mTOR signaling and Trp53 loss determine the heterogeneity and excitability of BRAFV600E-induced brain tumors in mice.