Gilles Huberfeld

This study shows that gangliogliomas induce developmental changes in cortical networks, leading to seizure dynamics that shift from neonatal to adult stages, with age-specific therapeutic implications.

This study evaluates photopharmacology agents in human and mouse brain tissue to control epilepsy, finding that caged propofol suppresses epileptiform activity across species.

The paper investigates GBM cell spreading in mouse and human brain tissue, identifying Cx43 upregulation as a key factor in tumor infiltration.

The paper identifies NKCC1 as a signaling hub that regulates KCC2 stability and chloride homeostasis, showing that peptides targeting NKCC1 can reduce seizure frequency in epilepsy.

This study uses megahertz-range single-pulse focused ultrasound to induce focal calcium waves in human neural cells, showing that radiation force at >5 MHz provides safer, more predictable stimulation than cavitation.

This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.

This paper develops a neural mass model incorporating spike-frequency adaptation to study seizure dynamics, showing adaptation and inhibition control pathological synchronization in epilepsy.