Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer survival benefit in aging
Lucie Orliaguet, Hee‐Hoon Kim, Piyush Gupta, Aileen Lee, Yuanjiu Lei, Ruiqi Li, Carisa Zeng, Yun‐Hee Youm, Tamara Dlugos, Chenyang Guan, Andrew Wang, Maxim N. Artyomov, Yuval Kluger, Björn Schumacher, Vishwa Deep Dixit
This study shows that reducing cysteine, not methionine, improves immunometabolic fitness and extends healthy lifespan in aging organisms.
bioRxiv · Sep 9, 2026 · PreprintPhysiology