Author

Chenyang Guan

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

Hee‐Hoon KimiD· 2 shared Lucie OrliaguetiD· 2 shared Tamara Dlugos· 2 shared Vishwa Deep DixitiD· 2 shared Yun‐Hee YoumiD· 2 shared Yuval KlugeriD· 2 shared Aileen Lee· 1 shared Albert C. ShawiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPhysiology

Hee‐Hoon KimORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer survival benefit in aging

Lucie Orliaguet, Hee‐Hoon Kim, Piyush Gupta, Aileen Lee, Yuanjiu Lei, Ruiqi Li, Carisa Zeng, Yun‐Hee Youm, Tamara Dlugos, Chenyang Guan, Andrew Wang, Maxim N. Artyomov, Yuval Kluger, Björn Schumacher, Vishwa Deep Dixit

This study shows that reducing cysteine, not methionine, improves immunometabolic fitness and extends healthy lifespan in aging organisms.

bioRxiv · Sep 9, 2026 · PreprintPhysiology

Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.

Chenyang Guan, Seungjin Ryu, Mingze Dong, Yun‐Hee Youm, Subhasis Mohanty, Rae Maeda, Lucie Orliaguet, Hee‐Hoon Kim, Tamara Dlugos, Steven R. Smith, Éric Ravussin, Janset Onyuru, Andrew Wang, Albert C. Shaw, Hal M. Hoffman, , Vishwa Deep Dixit

This study shows that elevated taurine reduces age-related inflammation by inhibiting the NLRP3 inflammasome and pyroptosis in mice.

bioRxiv · May 27, 2025 · PreprintImmunology