Vishwa Deep Dixit

Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer survival benefit in aging

This study shows that reducing cysteine, not methionine, improves immunometabolic fitness and extends healthy lifespan in aging organisms.

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging

The paper identifies complement deactivation as an immunometabolic checkpoint reduced by calorie restriction, which lowers inflammaging in humans and mice.

Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation

This study identifies nerve-associated macrophages (NAMs) as regulators of adipose homeostasis and inflammation during aging, showing their depletion accelerates inflammaging and impairs lipolysis.

Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.

This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.

Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.

This study shows that elevated taurine reduces age-related inflammation by inhibiting the NLRP3 inflammasome and pyroptosis in mice.

Epigenetic aging of classical monocytes from healthy individuals

This study characterizes epigenetic aging in human classical monocytes, identifying age-associated DNA methylation changes and their links to gene expression and disease associations.