Author

Yun‐Hee Youm

Yale UniversityORCID 0000-0002-8098-8527Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Tamara Dlugos· 4 shared Vishwa Deep DixitiD· 4 shared Éric RavussiniD· 3 shared Hee‐Hoon KimiD· 3 shared Lucie OrliaguetiD· 3 shared Maxim N. ArtyomoviD· 3 shared Albert C. ShawiD· 2 shared Chenyang Guan· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersPhysiology

Tamara Dlugos

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4 papers

Recent·Most cited

Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer survival benefit in aging

Lucie Orliaguet, Hee‐Hoon Kim, Piyush Gupta, Aileen Lee, Yuanjiu Lei, Ruiqi Li, Carisa Zeng, Yun‐Hee Youm, Tamara Dlugos, Chenyang Guan, Andrew Wang, Maxim N. Artyomov, Yuval Kluger, Björn Schumacher, Vishwa Deep Dixit

This study shows that reducing cysteine, not methionine, improves immunometabolic fitness and extends healthy lifespan in aging organisms.

bioRxiv · Sep 9, 2026 · PreprintPhysiology

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging

Manish Mishra, Hee‐Hoon Kim, Yun‐Hee Youm, Elsie Gonzalez-Hurtado, Konstantin Zaitsev, Tamara Dlugos, Irina Shchukina, Christy M. Gliniak, Éric Ravussin, Subhasis Mohanty, Albert C. Shaw, Philipp E. Scherer, Maxim N. Artyomov, Vishwa Deep Dixit

The paper identifies complement deactivation as an immunometabolic checkpoint reduced by calorie restriction, which lowers inflammaging in humans and mice.

Nature Aging · Apr 13, 2026Peer-reviewedPhysiology

Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.

Aileen H. Lee, Lucie Orliaguet, Yun‐Hee Youm, Rae Maeda, Tamara Dlugos, Yuanjiu Lei, Daniel Coman, Irina Shchukina, Prabhakar Sairam Andhey, Steven R. Smith, Éric Ravussin, Krisztián Stadler, Bandy Chen, Maxim N. Artyomov, Fahmeed Hyder, , Vishwa Deep Dixit

This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.

Nature Metabolism · Jun 3, 2025Peer-reviewedPhysiology

Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.

Chenyang Guan, Seungjin Ryu, Mingze Dong, Yun‐Hee Youm, Subhasis Mohanty, Rae Maeda, Lucie Orliaguet, Hee‐Hoon Kim, Tamara Dlugos, Steven R. Smith, Éric Ravussin, Janset Onyuru, Andrew Wang, Albert C. Shaw, Hal M. Hoffman, , Vishwa Deep Dixit

This study shows that elevated taurine reduces age-related inflammation by inhibiting the NLRP3 inflammasome and pyroptosis in mice.

bioRxiv · May 27, 2025 · PreprintImmunology