Noah Peña

Three immunoregulatory signatures define non-productive HIV infection in CD4+ T memory stem cells

This study identifies three immunoregulatory signatures in non-productive HIV-infected CD4+ T memory stem cells, highlighting their distinct transcriptomic profile and potential role in immune evasion.

Modifications in the T arm of tRNA globally determine tRNA maturation, function and cellular fitness

This study shows that tRNA modifications in the T arm by TrmA and TruB are essential for tRNA maturation, aminoacylation, and translation, enhancing cellular fitness in E. coli.

Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast

A de novo yeast neochromosome carrying all 275 tRNA genes was built and characterized; it imposes a growth burden, with genome doubling and deletions in haploids possibly reflecting compensation.