Epithelial state-transitions permit inflammation-induced tumorigenesis.
Edward J. Jarman, Anabel Martinez Lyons, Yuelin Yao, Aleksandra Rozyczko, Scott H. Waddell, Andreea Grãdinaru, Paula Olaizola, Kyle Davies, Rachel Victoria Guest, Stephanie K. Roessler, Timothy James Kendall, Owen James Sansom, Ava Khamseh, Luke Boulter
This study identifies epithelial state transitions driven by inflammation that promote tumorigenesis, showing that targeting NOTCH signaling can prevent pre-neoplastic to neoplastic transition.
bioRxiv · Jun 22, 2025 · PreprintCancer Biology