Scott H. Waddell

Epithelial state-transitions permit inflammation-induced tumorigenesis.

This study identifies epithelial state transitions driven by inflammation that promote tumorigenesis, showing that targeting NOTCH signaling can prevent pre-neoplastic to neoplastic transition.

Tissue scarring provides a biomechanical framework to promote mammalian bile duct regeneration through the activation of integrin-SRC/FAK signalling.

This study shows that collagen scar formation during bile duct regeneration alters biomechanical properties, activating integrin-SRC/FAK signaling to drive ductular regeneration through a leading-tip of integrin-2-high cells.

Planar cell polarity is essential for the architectural patterning of the mammalian biliary tree.

This study shows that planar cell polarity, mediated by VANGL2, is essential for the proper formation and architecture of the mammalian biliary tree.