Author

Edward J. Jarman

University of LeicesterORCID 0000-0002-5466-4430Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Luke BoulteriD· 3 shared Anabel Martinez LyonsiD· 2 shared Andreea GrãdinaruiD· 2 shared Kyle Davies· 2 shared Paula OlaizolaiD· 2 shared Scott H. WaddelliD· 2 shared Timothy James KendalliD· 2 shared Yuelin YaoiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCell Biology

Luke BoulterORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 27, 2025

JMJD5 regulates metabolism by hydroxylating ISY1, and regulating the Arginine Methyltransferase PRMT6

Zaid Khan, Chartinun Chutoe, Jair Gonzalez Marques Júnior…·Alexander von Kriegsheim

This paper identifies JMJD5-ISY1-PRMT6 as a pathway regulating metabolism by hydroxylating ISY1 to inhibit PRMT6, showing its role in liver cancer and potential as a therapeutic target.

1 citation

mouseexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJun 22, 2025

Epithelial state-transitions permit inflammation-induced tumorigenesis.

Edward J. Jarman, Anabel Martinez Lyons, Yuelin Yao…·Luke Boulter

This study identifies epithelial state transitions driven by inflammation that promote tumorigenesis, showing that targeting NOTCH signaling can prevent pre-neoplastic to neoplastic transition.

DOI 10.1101/2025.06.22.660911

mousebulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintApr 21, 2025

Tissue scarring provides a biomechanical framework to promote mammalian bile duct regeneration through the activation of integrin-SRC/FAK signalling.

Alexander Walker, Paula Olaizola, Euan Brennan…·Luke Boulter

This study shows that collagen scar formation during bile duct regeneration alters biomechanical properties, activating integrin-SRC/FAK signaling to drive ductular regeneration through a leading-tip of integrin-2-high cells.

1 citation

mousescRNA-seq

𝕏 PostBluesky