Author

Alessandro Porrello

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:protein sequence· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1

Frequent Co-Authors

Andrea GiansantiiD· 2 shared Antonio Deiana· 2 shared J. Mauro CalabreseiD· 2 shared Quinn E. EberhardiD· 2 shared Sergio ForcelloniiD· 2 shared Zhiyue ZhangiD· 2 shared Christine A. MillsiD· 1 shared Daniel DomingueziD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Andrea GiansantiORCID

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Author profile →

4 papers

Recent·Most cited

Xist Repeat A coordinates an assembly of SR proteins to recruit SPEN and induce gene silencing

Jackson B. Trotman, Alessandro Porrello, Scott A. Schactler, Lorenzo E. DeLeon, Quinn E. Eberhard, Samuel P. Boyson, Zhiyue Zhang, Shuang Li, David M. Lee, Sarah E. Kirik, Nadia Sultana, Son N. Nguyen, Michael-Claude G. Beltejar, Min Kyung Shinn, Shao-En Ong, , J. Mauro Calabrese

The paper identifies how Xist Repeat A recruits SPEN via SR proteins to induce gene silencing, revealing a role for splicing factors in this process.

bioRxiv · May 21, 2025 · PreprintGenetics

SAFB associates with nascent RNAs to promote gene expression in mouse embryonic stem cells

Rachel E. Cherney, Quinn E. Eberhard, Christine A. Mills, Alessandro Porrello, Zhiyue Zhang, David White, Laura E. Herring, J. Mauro Calabrese

This study identifies SAFB-associated RNAs in mouse embryonic stem cells and shows SAFB promotes gene expression by binding purine-rich regions in nascent transcripts.

bioRxiv · Dec 20, 2022 · PreprintMolecular Biology

Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cell

Antonio Deiana, Sergio Forcelloni, Alessandro Porrello, Andrea Giansanti

The paper classifies human proteins into three categories based on disorder and shows IDPs and IDPRs have distinct functional roles and disease associations.

PLoS ONE · Aug 19, 2019Peer-reviewedBioinformatics

New Classification of Intrinsic Disorder in the Human Proteome

Antonio Deiana, Sergio Forcelloni, Alessandro Porrello, Andrea Giansanti

The paper introduces a new classification of human intrinsically disordered proteins based on sequence parameters, distinguishing five variants and highlighting functional and compositional differences between PDRs and IDPs.

bioRxiv · Oct 17, 2018 · PreprintBioinformatics