Author

Shuang Li

Tsinghua University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Alessandro Porrello· 1 shared Carla Vazquez Amos· 1 shared Chenqu SuoiD· 1 shared Chong ZhangiD· 1 shared Christopher J. Steel· 1 shared Daniel DomingueziD· 1 shared David M ShechneriD· 1 shared David M. LeeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperGenetics

Alessandro Porrello

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Author profile →

3 papers

Recent·Most cited

In-situ Target Base Editing Combining with Biosensor-driven Strategy Reveals Critical Single Nucleotide Variants for Enhanced Recombinant Protein Secretion in Pichia pastoris

Yaomeng Yuan, Xihao Liao, Yujing Tang, Shuang Li, Kaho Hasegawa, Yi Wang, Xin‐Hui Xing, Chong Zhang

The paper develops a strategy combining genome editing and biosensor-assisted sorting to identify SNVs enhancing recombinant protein secretion in Pichia pastoris, achieving a high rHSA titer.

bioRxiv · Apr 10, 2026 · PreprintSynthetic Biology

Single-Cell Profiling Reveals Developmental Trajectories and identifies SYK and TIM3 as Targets in some T Cell Lymphomas

Ruoyan Li, Jamie D. Matthews, Emily R. James, Carla Vazquez Amos, Olli Dufva, Shuang Li, Christopher J. Steel, Lorenz Kretschmer, Chenqu Suo, Philip Turton, Ruth F. Jarrett, Ekaterina M. Shelomentseva, Egor Volchkov, Dmitry Abramov, Maria‐Myrsini Tzioni, , Suzanne Dawn Turner

This study uses single-cell transcriptomics to analyze T cell lymphomas, identifies developmental origins, and discovers SYK and TIM3 as potential therapeutic targets.

bioRxiv · Mar 30, 2026 · PreprintCancer Biology

Xist Repeat A coordinates an assembly of SR proteins to recruit SPEN and induce gene silencing

Jackson B. Trotman, Alessandro Porrello, Scott A. Schactler, Lorenzo E. DeLeon, Quinn E. Eberhard, Samuel P. Boyson, Zhiyue Zhang, Shuang Li, David M. Lee, Sarah E. Kirik, Nadia Sultana, Son N. Nguyen, Michael-Claude G. Beltejar, Min Kyung Shinn, Shao-En Ong, , J. Mauro Calabrese

The paper identifies how Xist Repeat A recruits SPEN via SR proteins to induce gene silencing, revealing a role for splicing factors in this process.

bioRxiv · May 21, 2025 · PreprintGenetics