Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall Scott Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell
This study resolves heterogeneity in targeted lipid nanoparticles (tLNPs) using biophysical methods, showing that subpopulation structure, not bulk properties, determines targeted RNA delivery.
Advanced Materials · Jul 21, 2026Peer-reviewedBioengineering