Kushol Gupta

This study identifies that SGLT2 inhibitors activate pantothenate kinase 1 (PANK1) in the human heart, enhancing coenzyme-A synthesis and fuel use, which may explain their clinical benefits in heart failure.

This study resolves heterogeneity in targeted lipid nanoparticles (tLNPs) using biophysical methods, showing that subpopulation structure, not bulk properties, determines targeted RNA delivery.

This paper develops a lipid nanoparticle co-delivering mRNA and a small molecule drug to treat oral cancer by enhancing chemotherapy and reshaping the tumor microenvironment.

This study presents the first structures of a Redondovirus Rep protein, revealing conformational changes linked to its helicase and endonuclease functions during viral DNA replication.

This study uses biophysical methods to characterize lipid nanoparticle properties and predict their transfection efficiency.

This study compares conventional and CENP-A nucleosomes using high-pressure SAXS, revealing differences in their conformational stability and response to pressure.

This paper introduces multi-stage-mixing (MSM) to control lipid nanoparticle (LNP) supramolecular structure, creating a core-then-shell arrangement that significantly improves mRNA and DNA-LNP performance.