Author

Hannah M. Yamagata

University of PennsylvaniaORCID 0000-0002-9525-7102Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Michael J. MitchelliD· 5 shared Marshall Scott PadillaiD· 4 shared Adele S. RicciardiiD· 3 shared Kushol GuptaiD· 3 shared Ryann A. JosephiD· 3 shared Ajay S. ThatteiD· 2 shared Andrew R. HannaiD· 2 shared David IssadoreiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersBioengineering

Michael J. MitchellORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses

Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall Scott Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell

This study resolves heterogeneity in targeted lipid nanoparticles (tLNPs) using biophysical methods, showing that subpopulation structure, not bulk properties, determines targeted RNA delivery.

Advanced Materials · Jul 21, 2026Peer-reviewedBioengineering

Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy

Marshall Scott Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna Narateapvathdey Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell

This paper develops a lipid nanoparticle co-delivering mRNA and a small molecule drug to treat oral cancer by enhancing chemotherapy and reshaping the tumor microenvironment.

Advanced Materials · Jul 14, 2026Peer-reviewedBioengineering

Automated and parallelized microfluidic generation of large and precisely-defined lipid nanoparticle libraries

Andrew R. Hanna, Sarah J. Shepherd, Gregory Datto, Rakan D. El-Mayta, Taigh Anderson, Isabel B. Navarro, Adele S. Ricciardi, Marshall Scott Padilla, Neha Srikumar, Shuran Zhang, Hannah M. Yamagata, Nuo Meng, Joshua R. Buser, Mohamad‐Gabriel Alameh, Michael J. Mitchell, David Issadore

This paper presents an automated microfluidic platform for generating large, precisely-defined lipid nanoparticle libraries and evaluates their physicochemical and transfection properties.

ACS Nano · Dec 26, 2025Peer-reviewedBioengineering

Anti-CD38-Targeted Piperazine-Derived Lipid Nanoparticles Overcome Hepatic Clearance for mRNA Delivery to Multiple Myeloma Cells In Vivo

Christian G. Figueroa‐Espada, Hannah C. Geisler, Ryann A. Joseph, Adele S. Ricciardi, Ann E. Metzloff, Joshua O. Acosta-González, Lulu Xue, Hannah M. Yamagata, Ajay S. Thatte, Michael J. Mitchell

This study develops anti-CD38 lipid nanoparticles for targeted mRNA delivery to multiple myeloma cells, improving tumor targeting and reducing hepatic accumulation.

bioRxiv · Nov 12, 2025 · PreprintBioengineering

Elucidating lipid nanoparticle properties and structure through biophysical analyses

Marshall Scott Padilla, Sarah J. Shepherd, Andrew R. Hanna, Martin Kurnik, Xujun Zhang, Michelle Chen, James Byrnes, Ryann A. Joseph, Hannah M. Yamagata, Adele S. Ricciardi, Kaitlin Mrksich, David Issadore, Kushol Gupta, Michael J. Mitchell

This study uses biophysical methods to characterize lipid nanoparticle properties and predict their transfection efficiency.

Nature Biotechnology · Oct 23, 2025Peer-reviewedBioengineering