Li Yuping

Bacteriophage genome-wide transposon mutagenesis

This study develops a phage transposon sequencing (TnSeq) platform to identify essential genes in bacteriophages, finding ~110 fitness-conferring genes in a jumbo phage model.

Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination

The paper presents Cryo-EM structures of the CRL2-ZYG11B complex with substrates, revealing how ZYG11B recognizes and ubiquitinates Gly/N-degrons to activate the NLRP1 inflammasome.

Chronic demyelination of rabbit lesions is attributable to failed oligodendrocyte progenitor cell repopulation.

This study shows that chronic demyelination in rabbit CNS is associated with reduced oligodendrocyte progenitor cell (OPC) repopulation, regardless of lesion size, and highlights species-specific differences in remyelination mechanisms.

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition

This study identifies prefrontal cortex long-range GABAergic projections to the hippocampus that enhance signal-to-noise ratio for object representations and promote object exploration.