Author

Alexander Seguin

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Li‐Huei TsaiiD· 2 shared Ravikiran M. RajuiD· 2 shared Abdurrahman Muhtaseb· 1 shared Alexis Davison· 1 shared Anjanet R. Loon· 1 shared Audrey LeeiD· 1 shared Cheng-Yi Yang· 1 shared Colin Staab· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Li‐Huei TsaiORCID

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2 papers

Recent·Most cited

DNA double-strand break signaling induces aberrant neuronal activity

Ping‐Chieh Pao, Liwang Liu, Lauren Ashley Watson, Audrey Lee, Alexander Seguin, Daiyun Dong, Samaa Rasheed, Colin Staab, Oisín King, Ute Geigenmüller, Jay Penney, Fan Gao, Abdurrahman Muhtaseb, Ravikiran M. Raju, Li‐Huei Tsai

This study shows that p53 activation via DNA damage response causes aberrant neuronal activity in neurodegenerative diseases, and inhibiting p53 reduces this activity in a human iPSC model.

bioRxiv · May 13, 2026 · PreprintNeuroscience

The role of cholinergic signaling in multi-sensory gamma stimulation induced perivascular clearance of amyloid

Nicolas Lavoie, Cristina Blanco‐Duque, Martin C. Kahn, Hiba Nawaid, Anjanet R. Loon, Alexander Seguin, Ravikiran M. Raju, Alexis Davison, Cheng-Yi Yang, Li‐Huei Tsai

This study shows that cholinergic signaling is crucial for GENUS-induced perivascular amyloid clearance in Alzheimer's mouse models.

bioRxiv · Nov 27, 2024 · PreprintNeuroscience