Hiba Nawaid

This study shows that reducing LINE-1 RNA in hippocampal neurons increases their firing capacity and expands neuronal ensembles, improving spatial memory but reducing pattern separation.

The paper identifies Wnt signaling defects and GSK3b overactivity as regulators of lipid accumulation in APOE4 oligodendrocytes, showing that inhibiting GSK3b reduces lipid droplets and improves myelination.

This study shows that cholinergic signaling is crucial for GENUS-induced perivascular amyloid clearance in Alzheimer's mouse models.