JMJD5 regulates metabolism by hydroxylating ISY1, and regulating the Arginine Methyltransferase PRMT6
Zaid Khan, Chartinun Chutoe, Jair Gonzalez Marques Júnior, Edward J. Jarman, Andreea Gradinaru, Anthony Tumber, Eidarus Salah, Martin Lee, Haya Al Siyabi, Philippe Emmanuel Gautier, Chinmayi Pednekar, Ann P. Wheeler, Christopher J. Schofield, Luke Boulter, Alexander von Kriegsheim
This paper identifies JMJD5-ISY1-PRMT6 as a pathway regulating metabolism by hydroxylating ISY1 to inhibit PRMT6, showing its role in liver cancer and potential as a therapeutic target.
bioRxiv · Sep 27, 2025 · PreprintCell Biology