Biochemical characterisation of fungal bioluminescence enzymes reveals substrate inhibition and secondary turnover of 3-hydroxyhispidin by H3H
Jonathan F. Burnett, Johannes Lang, Anthony Tumber…·Patrick Rabe
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University of OxfordORCID 0000-0003-1958-8353Unclaimed ORCID profile · follow to get notified of new preprints
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4 papers
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Jonathan F. Burnett, Johannes Lang, Anthony Tumber…·Patrick Rabe
Katja Thümmler, Shyam Basak, Heather Hulme…·Daniel M. Wall
This study investigates the systemic effects of microbiome-derived carnitine analogues in mice, showing carnitine depletion and mitochondrial dysfunction due to inhibition of carnitine biosynthesis.
Zaid Khan, Chartinun Chutoe, Jair Gonzalez Marques Júnior…·Alexander von Kriegsheim
This paper identifies JMJD5-ISY1-PRMT6 as a pathway regulating metabolism by hydroxylating ISY1 to inhibit PRMT6, showing its role in liver cancer and potential as a therapeutic target.
Hannah B. L. Jones, Simeon D. Draganov, Sofia Schönbauer Huamán…·Adán Pinto-Fernández
This paper introduces a high-throughput activity proteomics pipeline for discovering deubiquitinase inhibitors, identifying potent and selective inhibitors with minimal optimization.