Pro-inflammatory role of granzyme K producing bystander CD8+ T cells in acute myeloid leukemia
Lisa Aziez, Nicolas Deredec, Ismaël Boussaid, Carolyn Shasha, Romain Vazquez, Chloé Friedrich, Ania Alik, Kanchanadevi Manasse, Zoé Fremont-Debaene, Alexandra Barthelemy, Cyril Catelain, Philippe Rameau, Marguerite Vignon, Justine Decroocq, Olivier Kosmider, , Yannick Simoni
This study identifies a pro-inflammatory role of Granzyme K-producing bystander CD8+ T cells in AML, which promote IL-8 secretion and may exacerbate disease progression.
bioRxiv · Aug 12, 2025 · PreprintImmunology