Interleukin-6 elevates thrombosis via pro-coagulant phospholipids from platelet 12-lipoxygenase in rheumatoid arthritis.
Daniela O. Costa, Stuart T.O Hughes, Robert L. Jenkins, Ana Cardus Figueras, Majd B. Protty, Victoria J. Tyrrell, Ali A Hajeyah, Gareth Wyn Jones, James J Burston, Beth Morgan, Federica Monaco, David Gregory Hill, Aisling S. Morrin, Carol Guy, Alice Bacon, , Valerie B. O’Donnell
This study identifies IL-6's role in elevating thrombosis in RA via platelet 12-lipoxygenase-generated pro-coagulant phospholipids.
bioRxiv · Mar 26, 2025 · PreprintPharmacology & Toxicology